Potential reproductive health effects and oxidative stress associated with exposure to potassium dichromate [K2Cr2O7] and magnesium sulphate [MgSO4] in male mice

To investigate the potential harmful effects of potassium dichromate and magnesium sulphate causing oxidative stress and reproductive toxicity in adult male mice model. The experimental work was conducted on sixty male mice [Mus musculus] divided into three groups. Mice in group B and C received potassium dichromate and magnesium sulphate of 5.0 and 500 mg/Kg body weight/ml respectively, for sixty days. The blood sample was analyzed to assess oxidative stress and cellular damage. Results showed high malondialdehyde [MDA] and low levels of antioxidant enzymes [catalase [CAT], superoxide dismutase [SOD] and glutathione peroxidase [GPx]] in both potassium dichromate and magnesium sulphate administrated groups as compared to control group. Reduced number of sperm count and excessive destruction of testicular follicles, including destruction of spermatids, leydig cells and sertoli cells, were also seen in both groups. We concluded from present study that potassium dichromate and magnesium sulphate causes oxidative stress by generation of reactive oxygen species [ROS] and causing DNA damage in testicular cells leading to adverse reproductive abnormalities

Comparative study of alterations in tri-iodothyronine [T3] and thyroxine [T4] hormone levels in breast and ovarian cancer

The present study was designed to investigate variations in the levels of thyroid hormones [T3, T4] in breast and ovarian cancers patients. A total 120 subjects were recruited [without thyroid history] divided into three groups; A, B and C. Group A as control with healthy individuals. While group B and group C were consisting of breast cancer and ovarian cancer patient respectively. Blood samples [5 ml] were taken and analyzed to estimate the levels of serum T3 [tri-iodothyronine] and T4 [thyroxin] hormones. Statistically significant difference [P=0.000* and P=0.017*] was obtained among all groups. A significant increase in T3 [P=0.000*] and T4 [0.005*] levels was observed among breast cancer patients as compared to healthy controls. While for ovarian cancer patients conflicting results were found for T3 and T4 levels in the serum i.e. insignificant difference was found in T3 [P=0.209] and T4 [P=0.050] as compared to control. Our results showed that in the breast cancer and ovarian cancer patients the thyroid hormone [T3 and T4] level has been altered from the normal ranges as compared to the normal healthy individuals. We conclude that hyperthyroidism has profound effects on breast cancer and ovarian cancer cells proliferation